A number of derivatives of 8-hydroxyquinoline has antibacterial, antiparasitic and protivogpibkovoy activity. Preparations of this series are used as chemotherapeutic agents and antiseptic. Salt (sulfate) unsubstituted 8-hydroxyquinoline is a well-known drug hinozol. In the mid-50s as an oral antibacterial and antiprotozoal drugs have become widely used compounds in this group, halogen substituents soderzhaschimie (chlorine, bromine, iodine) in position 5 and 7 of the quinoline nucleus. Widely known, in particular, preparations enteroseptol (5-chloro-7-iodo-8-hydroxyquinoline) [synonyms: Chinoform, Enteroquinol, Enteroseptol, Enterusan, Vioform and others], meksaza (enteroseptol in conjunction with the enzyme preparation, and bromelin dehydrocholic acid) and meksaform (Mexaform), sodepzhahhij enteroseptol with fenantpolin-quinone (Entobex, Phanquinon), which is also an antibacterial agent. These drugs have proved effective for the treatment of intestinal infections: putrefactive and fermentative dyspepsia, enterocolitis, amoebic and bacillary dysentery, protozoal colitis, etc. However, it was found that these drugs (especially with prolonged use) can cause side effects: peripheral neuritis, myelopathy, and lesions the optic nerve and liver damage and kidney failure, allergic reactions. Therefore, this group of drugs are used very sparingly. Intestinal infections in this group used drugs and combination drug hlorhinaldola intestopan and urogenital infections with A HREF = “drug1407.htm”> nitroksolin. Recently, extensive use was another group of quinoline derivatives – 4 – quinolones, especially fluoroquinolones.